
Johannesburg is vast, so most visitors pick a well-connected node like Sandton or Rosebank rather than a single "city centre".
Sandton is the upmarket business hub, safe and served by the Gautrain to the airport. Rosebank is smaller, walkable and arty, with great restaurants and markets.
Melville and Maboneng offer nightlife, galleries and a grittier city energy, better for repeat visitors comfortable in the city.
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Sandton and Rosebank are the most popular for visitors, thanks to security, dining and the Gautrain link.
The Gautrain runs from the airport to Sandton in about 15 minutes, avoiding traffic.
Yes, for Soweto, Constitution Hill, the Apartheid Museum and as a gateway to the rest of the country.